2 SUBSTITUTED 4 2 DIALKYLAMINOETHYL THIAZOLES

SCHOLZC, R; MIZZONIR, H; DJERASSI, CARL

doi:DOI: 10.1021/jo01149a042

2 SUBSTITUTED 4 2 DIALKYLAMINOETHYL THIAZOLES

Date

1951

Authors

SCHOLZC, R

MIZZONIR, H

DJERASSI, CARL

Publisher

CIBA PHARMACEUTICAL PRODUCTS, RESEARCH DEPARTMENT DIVISION OF CHEMISTRY, SUMMIT, NJ, EUA
LABORATORIOS SYNTEX, CD. MEXICO, DF, MEX

Abstract

1-Bromo-4-dialkylaminobutan-2-one hydrobromides, obtainable from the corresponding "Mannich bases", were condensed with (a) aryloxyacetothioamides to yield a series of 2-(aryloxymethyl)-4-(2-dialkylaminoethyl)thiazole dihydrobromides; (b) thioformamide, t