THE PREPARATION OF TWO AROMATIC ANALOGS OF DESOXYCORTICOSTERONEACETATE
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CIBA PHARMACEUTICAL PRODUCTS, RESEARCH DEPARTMENT DIVISION OF CHEMISTRY, SUMMIT, NJ, EUA
LABORATORIOS SYNTEX, CD. MEXICO, DF, MEX
LABORATORIOS SYNTEX, CD. MEXICO, DF, MEX
Abstract
Two syntheses of 3-methoxy-17-(β-acetoxyacetyl)-1,3,5-estratriene (III), an aromatic analog of desoxycorticosterone acetate, are described. The first procedure involved hydroxylation of 17-vinylestradiol methyl ether (Vb) with osmium tetroxide followed b